Items and character unlocks can also be purchased via an in-game currency, obtained either during combat modes or by purchasing directly using real-world currency. Outside of combat modes, the player is returned to the ' Crib', where they can manage inventory, select characters, or craft weapons and other items. Items can be anything from crafting components to weapons to Blueprints.

Various items can be obtained via combat, either in the course of gameplay or as a reward for completing certain tasks. Specific objectives vary depending on the mode of combat, but in all modes Walkers, Infected, and various Special Zombies spawn and attack the player, and must be killed or avoided.

The player controls one of several selectable characters, initiating special attacks and moving via the keyboard, while initiating basic attacks and aiming via the mouse. Sinamoi discovers that his rescuers are themselves infected, but unlike the normal mindless hordes 'the virus is making them stronger, smarter.' He decides to stay with these new survivors, and help them as they gather supplies and fend off the undead.Дead Island: Epidemic is played from a third-person overhead isometric perspective. As John braces himself for his seemingly inevitable death he is unexpectedly rescued by a group of survivors, who start 'tearing up the infected like a pack of wild dogs' using scavenged and makeshift weapons, saving Sinamoi's life. Unfortunately, Amaia has been struck by the same Kuru virus which caused the outbreaks on Banoi Island, Narapela Island and Palanai Island, and Sinamoi soon finds himself surrounded by zombies and other infected. After the events of Dead Island, John Sinamoi escapes from the horrors of Banoi Island, making his way to Amaia Island to find safety.

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